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The stomach's acidic pH (1.5-3.5) and proteolytic enzymes present major challenges for peptide stability

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The maintenance dosethe amount you'll continue using long-termis often 1.0 mg or 2.4 mg weekly, though some individuals find lower doses effective and sustainable

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Theoretical or documented interactions include: Immunosuppressants (particularly ciclosporin, where clinical interaction has been documented) Medications metabolised by CYP3A4 or CYP2D6 enzymes Medications that are P-glycoprotein substrates Consult your pharmacist or GP before taking berberine alongside any regular medications, particularly those with a narrow therapeutic window