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Copper Exposure, Sensitivity, and Long-Term Safety Gaps Copper is biologically essential, but copper exposure is not automatically harmless, especially if a formulation changes systemic exposure or bypasses normal skin barriers

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91 It is unclear whether the heart rate increase associated with GLP-1 RAs, which may pose a safety concern in patients with HFrEF, can be mitigated by the concurrent use of -blockers, which are typically prescribed for HFrEF

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