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PLoS ONE 9 , e89977 (2014)

In a skeletonized face, facial fat (which forms the faces cushioning) atrophies and bony ridges are accentuated

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Glatter: In practice, many patients labeled non-responders to GLP-1 therapy are experiencing incomplete dosing, early discontinuation because of gastrointestinal side effects, insufficient treatment duration, or competing metabolic drivers such as severe insulin resistance, sleep disruption, sarcopenia, or medication-associated weight gain