Dairy products : Including whole milk and cheese
People lost up to 24% of their body weight over 48 weeks in Phase 2 trials published in the New England Journal of Medicine in 2023
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The most common side effects were stomach issues nausea, vomiting, diarrhea
Additionally, proteolytic degradation is a major challenge in peptide-based therapeutics, as it results in short half-life, low bioavailability, rapid clearance, and ultimately reduced therapeutic efficacy