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Indeed, loss of GPX4 expression and activity specifically in monocytes/macrophages triggers ferroptosis in IL-4-driven macrophage differentiation, while sparing inflammatory macrophages, which were able to sustain cell survival and function in the absence of GPX4

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This approach reduces per-dose cost, minimizes waste, and requires fewer reconstitutions

Weight Loss Observed Across the Studies The weight loss observed at 52 weeks with tirzepatide (10 mg and 15 mg) across the two studies was nearly 20% in a patient population that was comprised of approximately 70% males, who are known to achieve less weight loss with incretin therapy than females

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