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These structural features improve peptide stability , extend half-life , and reduce amyloid fibril formation relative to native amylin, supporting sustained activity in experimental systems
These include lifestyle modification requirements (69%), trialing lower-cost medications first (63%) and limiting therapy duration (63%)
Initial dosages for PDA recommended by 1
Influence of gastric inhibitory polypeptide antiserum on glucose-induced insulin secretion in rats
Another PSMA-based ADC investigated for the treatment of mCRPC, MEDI3726, also had similar issues with delivering its pyrrolobenzodiazepine (tesirine, SG3249) payload to the tumor without off-target effects due to heavy-light chain dissociation in the antibody 75
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