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The Food and Drug Administration (FDA) has approved Eli Lillys once-daily oral GLP-1 receptor agonist, orforglipron, for adults with obesity, or overweight with weight-related medical problems

This combination creates blood sugar volatility (spike from sugar, crash from alcohol liver inhibition) and adds hundreds of empty calories that directly undermine your weight loss progress

"These medications act on hormones that can affect taste," said Mir Ali, medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center, noting that patients who undergo gastric bypass may also experience changes to their gut hormones that can change their sense of taste

In a new study reported in The Lancet, Tirzepatide, a GLP-1R/GIPR agonist, reduced alcohol's rewarding properties, locomotor stimulation, conditioned place preference, and accumbal dopamine release