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Quercetin Dose, Metabolism and Toxic Metabolites Quercetin is one such example where both dose and metabolism are determining factors in achieving the desired clinical outcomes safely and effectively
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Is reactive oxygen species production elevated
These signals impact collagen synthesis, elastin organization, and overall extracellular matrix quality
Some recent work aimed to develop tamoxifen analogues that can bypass CYP2D6 metabolism and use the esterase enzymes to produce the active metabolites to ensure equal clinical outcomes for all patients [66,67,68]
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