Notably, at physiological concentrations, TMAO can enhance the integrity of the bloodbrain barrier through the tight junction regulator annexin A1, limit the reactivity of astrocytes and microglia, and protect the cognitive function of mice from inflammatory challenges
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Notably, injected PDCs from AR flox/Y mice also increased callus volume and new bone formation not only in both AR flox/Y but also in AR -/Y ;Prrx1::Cre mice (Fig