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As I discussed on Episode 80 of our podcast, The Future of GLP-1 Medications: Quick Pen and Dose Flexibility, our dilution approach has allowed patients to reduce their medication costs by a third or even a sixth of the traditional cost

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It was conducted by the 23andMe Research Institute and published in Nature on 8 April 2026

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The Core Benefits of Microdosing Liver and Cardiovascular Protection A 72-week trial found 40% of patients achieved resolution of fatty liver disease without worsening fibrosis. In animal models, GLP-1s suppress fat production in the liver and reduce inflammation. Tirzepatide at low doses showed particularly strong cardiovascular benefits, with meaningful improvements across multiple lipid markers linked to heart disease risk. Cholesterol storage forms increased far less with tirzepatide, and harmful lipids like ceramides showed minimal increase compared to placebo