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Severe hyponatremia can progress to seizures or coma
PDE2A shows regionally divergent alterations in schizophrenia, with reductions in the amygdala, cingulate cortex, and orbitofrontal cortex but elevated expression in the hippocampus, suggesting compensatory rather than pathogenic involvement
adult population are obese, most having comorbidities, and now close to 10% meet criteria for class 3 or morbid obesity, which is a very serious problem
This creates a concentration of 2,500 mcg/mL (2.5 mg/mL)
doi: 10.1172/jci.insight.180114 24 SousaCMBiancurDEWangXHalbrookCJShermanMHZhangLet al
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