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This is why many patients report that appetite suppression strengthens during their first month of treatmentnot because individual doses get stronger, but because cumulative medication concentration climbs

The SURMOUNT-5 trial directly compared the two medications and found tirzepatide produced approximately 20 percent weight loss compared to 14 percent for semaglutide

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95% CI, 0.86-0.94), schizophrenia and other psychotic disorders (HR = 0.82

I switched full time to Rt in a 2 month transition