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Cortisol and ACTH are hormones potentially involved in the stress response and are typically associated with various metabolic and immune actions

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The original in-vitro finding The foundational study is Khavinson, Bondarev, and Butyugov (2003), who reported that adding Epithalon to cultures of telomerase-negative human fetal fibroblasts induced expression of the telomerase catalytic subunit, restored telomerase enzymatic activity, and produced telomere elongation

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Post-hoc analysis revealed a significant difference ( p 30