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* Manufacturer: The approval was granted to Novo Nordisk

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Administration routes include subcutaneous injection (via syringe, pen, or continuous subcutaneous insulin infusion pump), intravenous infusion (restricted to monitored clinical settings), and, more recently, inhaled insulin for prandial coverage

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The glucagon receptor agonism in retatrutide is thought to be the key driver here glucagon promotes hepatic lipid oxidation, essentially helping the liver burn its own fat stores