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Phentermine has been used since the 1950s as a sympathomimetic amine, while GLP-1 agonists like semaglutide are newer peptide-based therapies approved for chronic weight management
Current evidence suggests the answer is yes
Extending the interval to 10 days creates a gap where medication levels drop below therapeutic thresholds, potentially reducing appetite suppression, metabolic benefits, and weight loss consistency
A STEP 1 extension found participants regained approximately two-thirds of lost weight within a year of stopping treatment (Wilding et al., 2022)
While severe oxidative stress can cause cell death, and even moderate oxidation can trigger abnormal cell death
