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Some studies have suggested that GLP-1 agonists could be associated with an increased risk of pancreatic issues, which could pose additional complications when considering pregnancy

Abstract Valproic acid (VPA) is a broad-spectrum antiepileptic drug and is usually well tolerated, but rare serious complications may occur in some patients receiving VPA chronically, including haemorrhagic pancreatitis, bone marrow suppression, VPA-induced hepatotoxicity (VHT) and VPA-induced hyperammonaemic encephalopathy (VHE)

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21/201 (10.5%) had pre-existing coronary artery disease (CAD) at time of presentation