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It participates in the tricarboxylic acid cycle and glucose metabolism within the body, and can activate various enzymes, such as sulfhydryl group (SH) enzymes and coenzymes, thereby promoting the metabolism of carbohydrates, fats, and proteins

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The study found an inverse relation between the emptying time from the gastric pouch, and plasma GLP-1 and insulin concentration with the meal, indicating that quicker transit time led to increases in insulin and GLP-1 plasma concentration and subsequent post-prandial hypoglycemia ( Exendin-(9-39) given as an intravenous infusion to adult individuals with post-prandial hypoglycemia after gastric bypass surgery led to a blunted insulin response, suggesting that GLP-1 is responsible for the exaggerated insulin secretion in dumping syndrome ( Conclusions The importance of incretin hormones on the regulation of glucose homeostasis through pancreatic and extra-pancreatic actions is well established

The medication remains effective for weight maintenance even if the appetite suppression feels less dramatic than it did initially

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