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Its chemical structure alteration, incorporating an acetyl group, enables it to traverse the blood-brain barrier, promoting brain health and energy production simultaneously

PMID 20306513

Ergothione is exclusively obtained through the diet (beans, livestock products, or mushrooms) and is converted to TMA by degrading the enzyme ergothionase

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TMAO has also been shown to induce inflammatory markers in mice and in human aortic endothelial cells and vascular smooth muscle cells owing to activation of MAPK, extracellular signal kinase, and NF-B signaling cascade, along with promoting the recruitment of activated leukocytes to endothelial cells