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Adiponectin levels are typically lower in individuals with obesity and metabolic disorders

Citation: Hughes, Tyler B., Grover Paul Miller, and S

AOP Development Strategy Context Used to provide background information for AOP reviewers and users that is considered helpful in understanding the biology underlying the AOP and the motivation for its development.The background should NOT provide an overview of the AOP, its KEs or KERs, which are captured in more detail below

This explains the typical presentation of adult males with signs and symptoms of hemochromatosis in the 4 th to 5 th decades, and the slightly later presentation of women, who have additional iron losses due to menstruation, pregnancy, and lactation