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These effects are mediated by: Gq-mER (Gq-coupled membrane ER)
The effects of bremelanotide on blood pressure (BP) have been well established in several clinical studies, which consistently show small, transient increases in BP that peak within 4 hours after dosing and return to baseline by approximately 8 to 10 hours
Some of these factors predict lower GLP-1 responses (higher weight or BMI, and high glucagon concentrations), while others are determinants of enhanced GLP-1 secretion (older age, higher fasting NEFA concentrations)
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