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GLP-1R is mainly expressed in islet -cells, where it mediates the insulinotropic effect of GLP-1 [27]
Participants were randomly assigned to receive maximum tolerated doses of either tirzepatide (10mg or 15mg) or semaglutide (1.7mg or 2.4mg) weekly for 72 weeks
It is expected to lead to expanded indications for semaglutide (potentially an indication for reduction of CV risk in obese patients)
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