These are portion-sized to suit reduced appetites and include nutrient-enriched options to compensate for lower overall food intake
On the cardiovascular side, the SUSTAIN-6 trial in 2016 was one of the first to report a significant reduction in major adverse cardiovascular events with semaglutide in adults with type 2 diabetes and high cardiovascular risk (Marso et al., NEJM, 2016)
Insulin Resistance: When a provider prescribes GLP-1 to treat insulin resistance or related metabolic issues, it may qualify for HSA and FSA coverage
The effect of retatrutide on bone density is also yet to be seen, although other GLP-1s have been shown to cause a decrease in bone density proportional to weight loss
Number one, cost and access will continue to be an issue because in our insurance system, which is unfortunately derived based off of BMI and the definition of obesity, there is also tremendous bias