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\Anti-inflammatory: Reduces TNF--induced IL-6 secretion in fibroblasts
Eligible studies included randomised controlled trials, cohort, and case-control studies assessing B12 supplementation efficacy via oral, sublingual, or IM administration routes
Investigators have studied the compound in combination with other research molecules, in biomaterial-integrated delivery formats, and in cell-type-specific contexts that broaden the mechanism understanding documented in foundational papers
Overuse or inappropriate administration may lead to nutrient imbalances
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