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Exclusion criteria were syndromic obesity, pregnancy, severe disease (including all forms of diabetes mellitus), abnormal QT-interval and any treatments influencing blood glucose, weight, or other parameters of the metabolic syndrome

Absorption Pathways Research suggests two main routes for intranasal glutathione: Intraneuronal pathway Glutathione enters neuronal pathways associated with the olfactory and trigeminal nerves, leveraging principles of overcoming oral cavity barriers that apply to various mucosal delivery routes

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Pregnant or nursing individuals should avoid GLP-1 support supplements, as with most supplements targeting metabolic pathways, due to insufficient safety data in these populations