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It occurs when the combined blood sugar-lowering effects of these medicines reduce glucose levels too far
insulin glargine The SURPASS-AP-Combo trial enrolled 917 adults with type 2 diabetes (age 18 years, inadequately controlled by previous metformin therapy and insulin-naive), who received tirzepatide 5 mg (n = 230), 10 mg (n = 228), 15 mg (n = 229), or insulin glargine (n = 230)
But how do they work, and how do they compare
Despite these benefits, intensive glycemic control in patients with diabetes can worsen diabetic retinopathy, a phenomenon known as early worsening, which typically occurs within the first year of intensive treatment [11]
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