The GIP receptor activation adds a second pathway for insulin secretion, glucagon suppression, and potentially adipocyte metabolism that semaglutide doesn't touch
It plays a crucial role in energy production by oxidising fats to energy for long-duration training
Raghavan S, Winter PS, Navia AW, Williams HL, DenAdel A, Lowder KE, Galvez-Reyes J, Kalekar RL, Mulugeta N, Kapner KS, Raghavan MS, Borah AA, Liu N, Vayrynen SA, Costa AD, Ng RWS, Wang J, Hill EK, Ragon DY, Brais LK, Jaeger AM, Spurr LF, Li YY, Cherniack AD, Booker MA, Cohen EF, Tolstorukov MY, Wakiro I, Rotem A, Johnson BE, McFarland JM, Sicinska ET, Jacks TE, Sullivan RJ, Shapiro GI, Clancy TE, Perez K, Rubinson DA, Ng K, Cleary JM, Crawford L, Manalis SR, Nowak JA, Wolpin BM, Hahn WC, Aguirre AJ, Shalek AK (2021) Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer
doi: 10.1016/j.foodres.2024.114000 69
And then when its connected to all sorts of inflammation and all sorts of various issues and what you were talking about earlier, impeding the absorption of certain nutrients, what do you think is going on