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A deficiency in B12 can increase susceptibility to infections and cause general fatigue

Medical and Evidence Context Vitamin B12 is essential for neurological function, red blood cell formation, DNA synthesis, and energy production

It is contraindicated for use in neonates and premature infants due to the risk of serious adverse reactions, including gasping syndrome

Moreover, S100A8/S100A9 complex binds to endothelial cells via the S100A9 subunit interacting chiefly with heparin and heparan sulfate proteoglycans (125), contributing to the immobilization of the myeloid cell-derived S100A8/S100A9 complex on endothelium in human inflammatory diseases

Vitamin B 12 is needed to prevent anemia, since making porphyrin and heme in mitochondria for producing hemoglobin in red blood cells depends on succinyl-CoA made by vitamin B 12