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nevertheless, knockdown experiments show that arrestin is involved in GLP-1-mediated insulin secretion (Sonoda et al., 2008)
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From these studies and from earlier observations in extreme cases of either glucagon deficiency or excess secretion, the physiological role of glucagon has expanded to also involve hepatic protein and lipid metabolism
For these individuals, medications such as Mounjaro or Wegovy may be more effective when used as part of a long-term management strategy rather than a defined short course
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