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The magnitude of response in this system is an integrated composite of the rate of Gs-Venus recruitment and activation (that will release the G protein from the activated receptor)

The animal literature is unusually consistent, though: nearly every published in vivo study used 5 mg/kg per injection, given three times on alternate days (days 1, 3, and 5, or days 14, 16, and 18 in the pulmonary fibrosis model), with effects tracked over the following three to four weeks