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Interestingly, SGLT2i and GLP-1RA have entirely different mechanisms of action

FIGURE 2 Patch-clamp studies testing the effects of bath-applied GLP-1 demonstrated that activating the receptor in hippocampal neurons evoked acute membrane potential changes, proving that GLP-1 receptors exist in the hippocampus and can induce acute neuronal changes ( 140 reduced the frequency of miniature inhibitory and excitatory postsynaptic currents (mEPSCs) (mIPSCs) in rat CA1 pyramidal neurons

When you melt away fat too quickly, either via diet, exercise or with medications like Ozempic, your hormonal system may interpret it as a stress event 2

Journal of Investigative Medicine

Small sample sizes can make drugs look much more or less effective than what they really are