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Although more difficult to discriminate in neurons, exendin(9-39) appeared not to be internalized in neurons in the ARC either, as was observed with the antagonist in cells. Finally, a comparative analysis using exendin(9-39) to block GLP-1R in the ARC showed that antagonizing the ARC, rather than the PVN, significantly reduced liraglutide's weight-loss effects, confirming the ARC as the primary target for long-term weight reduction

Contents Not that long ago, most people only thought about their metabolism when something went wrong like gaining weight or dealing with blood sugar issues

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By contrast, the structure of -gl u tide GLP analogs is based on h u man GLP-1