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Amylin, a neuroendocrine anorexigenic polypeptide hormone, with its multi-faceted effects in glucose regulation, weight management and potential CV and neuroprotective functions, represents an attractive new therapeutic target, albeit not without challenges and limitations [29]

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Furthermore, metformin diminishes the presence of Bacteroides fragilis , a bacterium that suppresses bile salt hydrolase activity, leading to a rise in secondary bile acids like GUDCA

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