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Rosen says

Increased glucose uptake

Safety and translation require evaluation of biodistribution, metabolism and clearance, and rigorous toxicology for repeated dosing, since commonly used polymers (alginate, hyaluronic acid, PEG are broadly biocompatible but longterm immunogenicity must be excluded [145]

These compounds work by mimicking hormones that regulate appetite and glucose metabolism, producing significant weight loss primarily through reduced food intake

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