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Users of those drugs are on the treadmill (no pun intended) for life

Is Persistent Hunger A Sign My Dose Is Too Low

The FDA Adverse Event Reporting System (FAERS) contains reports of musculoskeletal complaints associated with GLP-1 use, but such reports do not prove causation and may reflect coincidental associations or other contributing factors

"Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial." Published in Nature Medicine, Accessed on November 13, 2023 at National Center for Biotechnology Information (NCBI)

This is often related to neurotransmitter imbalances and to problems with the balance of good and bad bacteria in the gut