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Although preterm labor (PTL) was once classified outside this category (179), about one-third of preterm births are associated with changes in placental ultrastructure typically seen in ischemic disease processes (180)

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30 Together, these processes reshape transcriptional landscapes, sustain CSC plasticity, rewire metabolic networks, and remodel the immune microenvironment, thereby enabling tumor cells to evade therapeutic pressure through multifactorial routes