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Once activated, caspase-3 initiates the cleavage of a downstream substrate, such as nuclear poly (ADP-ribose) polymerase (PARP), which facilitates cellular disassembly and serves as a biomarker of cell apoptosis
Human data are extremely limited
The trial status is listed as "Unknown" it was reportedly cancelled in 2016, and no results were ever published
It is prohibited by the World Anti-Doping Agency for any athlete subject to drug testing
This bypasses the skin barrier that limits topical absorption, allowing higher concentrations to reach the dermis and deeper tissue layers
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