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Acknowledgements This project was supported by Fundao de Amparo Pesquisa e Inovao do Estado de Santa Catarina (FAPESC), Universidade do Extremo Sul Catarinense (UNESC), Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico of Brazil (CNPQ), and Fundao Coordenao de Aperfeioamento de Pessoal de Nvel Superior of Brazil (CAPES)

Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation via fibroblast and ex-vivo skin tests

-20C (freezer) for long-term storage

Phase 2 combination trials reported 35-40% discontinuation rates due to GI side effects when both agents were dosed simultaneously

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