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You shouldnt take it if youre pregnant (or trying to conceive) or breastfeeding, as its effects on fetuses and babies hasnt been studied
When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted
(9) Wrigley S, Arafa D, Tropea D
You get both working without going from zero to nightly retinol
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