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Starting at 250-300mcg regardless of body weight, then adjusting based on response, often works better than jumping to weight-based higher doses
For these six subjects, baseline GSH levels were all assigned the same value (the lowest measured GSH/Cr ratio value across all subjects and scans, divided by 2), in order to calculate the absolute change in GSH/Cr ratio relative to baseline
The authors attributed the increased risk to activation of cytochrome P450 2E1 by alcohol and depletion of glutathione stores by starvation or alcohol abuse
References This article is based on research from peer-reviewed medical journals, FDA documentation, manufacturer prescribing information, and clinical guidelines
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