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GLP-1R activation of neuroprotective pathways in neurons, microglia and astrocytes has also been reported: improvements in overall cognition, learning and motor function potentially associated with GLP-1RA administration in Alzheimers disease and Parkinsons disease may be mediated not only by their amyloid pathology-ameliorating properties (A, tau and -synuclein), but also the suppression of Ca 2+ deregulation and endoplasmic reticulum stress, anti-inflammatory activity, blockage of oxidative stress, mitochondrial dysfunction and apoptosis pathways, enhancements in the neuronal insulin sensitivity and energy metabolism, functional improvements in autophagy and mitophagy, elevated brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis, and neurogenesis 36

Switching from the Injection to the Tablet If you're considering switching from the weekly injection to the daily tablet, this should be done under medical supervision

For a 250-pound man, that difference translates to roughly 14 additional pounds lost

Let your provider know if you notice any side effects so they can make sure your medication dosage is appropriate

Your dose schedule should continue exactly as prescribed by your provider, whether you are on a weekly injection or daily oral formulation