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Side effects are common: about 43% of people felt nauseous, 33% had diarrhea, and about 1 in 5 experienced tingling or burning skin sensations (called dysesthesia) at the highest dose
GLP-1s have been on the market to help manage Type 2 diabetes since the early 2000s
Clinical Study Results (TRIUMPH & TRANSCEND) Retatrutide is an investigational triple agonist targeting GLP-1, GIP, and glucagon receptors: Weight reduction: In phase 2 and phase 3 clinical studies, treated participants achieved approximately 24% to 28.7% weight loss over 4868 weeks
Most GLP-1 medications start at a low dose and gradually increase every four weeks to minimize gastrointestinal side effects
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