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A larger randomized, placebo-controlled intervention trial (the SELECT study) in more than 35,000 middle-aged and selenium-replete men, randomized to receive selenium (in the form of selenomethionine, 200 g/day) and/or vitamin E supplementation, was halted because of concerns regarding an increased risk of type 2 diabetes mellitus with selenium and increased risk of prostate cancer with vitamin E (84, 85)
Preventing Over-treatment: While B12 is a water-soluble vitamin and is generally considered safe, injections are a medical procedure
2021;11:e390
Glutathione is generally well-tolerated, making it a gentler option for those looking to support their health without potential side effects
These shifts in the redox state can modulate key signaling pathways that govern cell fate, such as NOTCH (Neurogenic locus notch homolog protein)
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