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While some studies demonstrate benefits in stroke recovery and vascular dementia, large-scale trials (particularly CASTA) failed to show superiority over placebo in primary outcomes
Common Side Effects When side effects occurred, they were typically mild, transient, and similar in frequency to placebo groups: Reported Adverse Effects Most Common (occurring in small percentage of participants): Mild to moderate headaches (most frequently reported, often resolving with continued use) Injection site reactions (minor redness, swelling, or irritation at injection site) Gastrointestinal effects (particularly at higher oral doses: mild nausea, diarrhea, flatulence) Fatigue (reported occasionally during initial adaptation period) Rare Events: One case of chest tightness was deemed possibly related to treatment in safety trials
A structural concern ran across all four Day 1 compounds: the free base versus acetate salt distinction
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