I would wake up, take the alendronate dose with a full glass of water, and then remain upright for at least 30 minutes (this helps to prevent GI irritation)
These peptide molecules possess several key characteristics, including disrupting cell membrane integrity, inhibiting DNA and protein synthesis, and interfering with cellular metabolic processes and cell wall biosynthesis (Li et al., 2018
[6] Murri M, Luque-Ramirez M, Insenser M, Ojeda-Ojeda M, Escobar-Morreale HF
To reduce nausea and digestive upset, its best to limit greasy, fried, or very heavy meals, sugary drinks, alcohol, and large portions
Older adults, for example, may be more prone to cramping due to natural changes in muscles as they age