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A relaxed LES means acid escapes more easily, even without excess pressure
A weekly jab to the stomach or thigh may not seem like the most desirable delivery mechanism for a drug, but so far its the most effective
The most pronounced differences were observed in gastrointestinal and metabolic events: nausea (combination: n = 9651 vs monotherapy: n = 38,030), vomiting (4383 vs 17,062), pancreatitis (1389 vs 6655), and hypoglycemia (773 vs 1778)
Choosing based on which one has more animal evidence is reasonable
Biol Psychiatry 48:732739 Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry JM (2002) Decreased serum brain-derived neurotrophic factor levels in major depressed patients
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