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If the medication is left out at room temperature for extended periods or exposed to high heat (like in a hot car), the proteins can denature. This means they lose their shape and, consequently, their ability to bind to your hormone receptors

G.CianiS.et al (2004)

Methods Materials For tissue culture Dulbeccos modified Eagles medium (DMEM), RPMI-1640 medium, hygromycin-B, and Fluo-4 acetoxymethyl ester were used (Invitrogen Carlsbad, CA)

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These thresholds are lower than Western standards due to higher cardiometabolic risk at lower body mass index levels in South Asian populations