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Figure 2 5 Clinical research progress and safety evaluation 5.1 Clinical efficacy studies Tirzepatide, a novel dual GLP-1 and GIP receptor agonist, has demonstrated remarkable efficacy in the management of type 2 diabetes and obesity, as evidenced by multiple high-quality clinical trials (43, 44)
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41,53 However, they are also distinct as successful second-phase insulin secretion requires synthesizing insulin and insulin vesicles, which are not thermodynamically favourable processes
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