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Abstract The development of osteoarthritis (OA) correlates with the expansion of senescent cells in cartilage, which contributes to an inflammatory microenvironment that accelerates matrix degradation and hampers cartilage generation
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However, it must be approached thoughtfully, under proper medical supervision, and with a clear understanding of both the potential benefits and limitations
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GHK-Cu supplies the extracellular matrix remodeling via collagen, glycosaminoglycans and the MMP-TIMP system as well as an antioxidant and growth-factor-inducing component
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