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Not surprisingly, among the predictive biomarkers and assays under development, a majority focusses on measuring AR activity and consist of transcriptomics signatures or genomics tools to measure ARs transcriptional output (e.g., ADT-RS score [41]) or ARs structural integrity (e.g., AR-ctDETECT [42])

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[Current understanding of stress-cardiovascular pathways] For verification: Chronic stress increases cardiovascular disease risk by approximately 27% in prospective studies

Philp, A.L