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The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity
The honest positioning is that DSIP is not a first-line approach to sleep complaints
Lu, Jie, Giuseppe Esposito, Caterina Scuderi, Luca Steardo, Laurent C
Although clinical trials have not demonstrated the effectiveness of these drugs in individuals with type-2 diabetes who do not have CVD, they are still widely recommended (52)
C.GuiramandJ.et al (2017)
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